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COVID-19 Research Trials

Current COVID-19 research trials at Southlake 

Study Title:  Anti-Coronavirus Therapies to prevent COVID-19 progression (ACT) Trial

SRHC Principal Investigator: Dr. Carter Thorne

Summary: The goal of this study is to test whether certain drugs can prevent disease progression. The drugs being tested are hydroxychloroquine or chloroquine, which are commonly used to treat malaria, rheumatoid arthritis or lupus; azithromycin, which is an antibiotic that is used to treat bacterial infections and interferon beta, which is commonly used to treat multiple sclerosis.

Study Population: COVID-19 positive inpatients and outpatients


Study Title:  Assessing the psychological, social, and economic impacts of an emerging pandemic (C19 Online Survey)

SRHC Principal Investigator: Janet Jeffrey, RN, PhD

Summary: To examine the psychological, social, and economic impacts of the COVID-19 pandemic at various stages of the outbreak. Special attention will be given to social isolation, as well as family and work related factors.

Study Population: All individuals who are at least 12 years of age

Link to Survey: COVID-19 Online Survey       


Study Title:  Risk of death or respiratory failure in patients with COVID-19 who received an ACE inhibitor, ARB, or NSAID: A Multicentre Cohort study [COVID-ACE/ARB/NSAID]

SRHC Principal Investigator: Dr. Yaariv Khayin

Summary:   A retrospective study investigating the association between use of ACE inhibitors, ARBs, or NSAIDs with all-cause mortality, intensive care unit (ICU) admission or respiratory failure requiring mechanical ventilation among hospitalized patients with a confirmed diagnosis of COVID-19.

Study Population: COVID-19 positive adults 40 years and older


Study Title:  Virtual Family-Based Treatment (FBT) during a global pandemic: Exploring early treatment response and remission rates in a child and adolescent eating disorder sample

SRHC Principal Investigator: Jessica Pereira PhD, C. Psych

Summary: To determine if FBT (Family Based Treatment) being utilized in the Eating Disorders Program at Southlake Regional Health Centre can be effectively delivered using a virtual platform

Study Population: Child and adolescent patients and their families who have/will participate in virtual FBT compared to a matched-sample of participants who received FBT prior to COVID-19 restrictions.


Study Title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients with Moderate to Severe COVID-19

SRHC Principal Investigator: Dr. Carter Thorne

Summary: To evaluate the safety and effectiveness of the investigational Study drug, EB05 (the investigational study drug) in

Study Population: Adults hospitalized patients with moderate to severe COVID-19


Study Title: Factors influencing the demand for facial plastics and the decision to undergo surgery during the COVID-19 pandemic

SRHC Principal Investigator: Dr. Richard Rival

Summary: to analyze the influence of COVID-19 related factors on the demand for facial plastic surgery and patient’s decision to undergo surgery during the pandemic.

Study Population: Adults over 18 who will be seen for surgical consults